Protein kinase C-dependent desensitization of HDL3-activated phospholipase C in human platelets.
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چکیده
منابع مشابه
Protein kinase C-dependent desensitization of HDL3-activated phospholipase C in human platelets.
In isolated human platelets, exposure of subfraction 3 high-density lipoprotein (HDL3) binding sites to high concentrations of HDL3 (1 mg/mL) causes rapid desensitization of HDL3 (50 micrograms/mL)-stimulated breakdown of phosphatidylcholine, as shown in approximately a 70% depression of the maximal 1,2-diacylglycerol release activity by phospholipase C. This desensitization is HDL3 dose depend...
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involved in receptor-phospholipase C coupling. Hence. the effect o f GTPlS] may result from an action at a guanine nucleotide-binding protein (GI ) acting closer t o the exocytotic site, as suggested in other systems, e.g. ,4glucuronidasc secretion from neutrophils 15 I and histamine secretion from mast cells 161. For amine storage granule secretion, such B GTPlSl action cannot be distal t o C ...
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ژورنال
عنوان ژورنال: Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
سال: 1994
ISSN: 1049-8834
DOI: 10.1161/01.atv.14.8.1321